Although a rare skin cancer and their metastatic potential estimated at <5%, it is Pleomorphic dermal sarcoma and atypical fibroxanthomas are closely related predict aggressive behavior and allow distinction from atypical fibro
Atypical Fibroxanthoma of the Skin With Metastasis ELSON B. HELWIG, MD,' AND DENNIS MAY, LTC, MC, USA? Cutaneous atypical fibroxanthoma (AFX) occurs in elderly persons as a small nodule or ulceronodule in actinically damaged skin of the head and neck area. The vast majority of AFX behave in a benign manner, and metastasis is rare.
Discussion Atypical fibroxanthoma (AFX) is typically a diagnosis of exclusion that requires histopathologic and immunohistochemical analysis to distinguish it from tumors with similar clinical and microscopic appearances. Histopathologically, AFX appears extremely abnormal, with a dermal proliferation of Atypical fibroxanthoma is a skin cancer often seen in sun-exposed areas. It resembles squamous cell carcinoma or basal cell carcinoma because of the presence of a pink papule or erosion. It is usually diagnosed only after biopsy. Tumors involving the dermis and superficial fat are termed atypical fibroxanthoma and rarely metastasize.
Koch M, Freundl AJ, Agaimy A, et al. Atypical Fibroxanthoma - Histological Diagnosis, Immunohistochemical Markers and Concepts of Atypical fibrous histiocytoma : Usually presents in younger patients, lacks prominent actinic changes and may have areas of classic dermatofibroma in the periphery of the tumor. Leiomyosarcoma : Usually positive for smooth muscle markers, such as smooth muscle myosin and desmin. Metastatic carcinoma : Background. Atypical fibroxanthoma (AFX) is a tumor that occurs primarily in older individuals after the skin of the head and neck has been damaged significantly by sun exposure and/or therapeutic Atypical fibroxanthoma is a skin cancer often seen in sun-exposed areas. It resembles squamous cell carcinoma or basal cell carcinoma because of the presence of a pink papule or erosion.
OBSERVATIONS: We describe herein a patient who developed metastatic disease in cervical lymph nodes.
Metastasis rarely occurs, but there is a high rate of local recurrence, especially in patients who are immunosuppressed. Atypical fibroxanthoma (AFX) is a dermal spindle-cell sarcoma that is considered a superficial and clinically benign presentation of pleomorphic dermal sarcoma, malignant fibrous histiocytoma, and undifferentiated pleomorphic sarcoma.
5. Glavin FL, Cornwell ML. Atypical fibroxanthoma of the skin metastatic to the lung.
Atypical fibroxanthoma (AFX) is a rare spindle cell neoplasm predominantly found on the head and neck of elderly individuals with sun‐damaged skin, with no evidence‐based guidelines for their management.
2020-07-07 Mayo Clinic dermatologic surgeon, Dr. Jerry Brewer discusses Atypical Fibroxanthoma. He tells us about the risk factors, diagnosis and treatment of this rar 2020-09-10 Atypical Fibroxanthoma is a rare cutaneous tumour first described in 1963 by Elson Helwig. It has been related to ultraviolet-induced damage and most frequently occurs in sun damaged head and neck skin. Other risk factors include trauma, burns, irradiation, xeroderma pigmentosum, and organ transplantation. 2020-10-14 Atypical fibroxanthoma with regional lymph node metastasis: report of a case and review of the literature. Arch Dermatol. 2010; 146(12):1399-404 (ISSN: 1538-3652) New D; Bahrami S; Malone J; Callen JP. BACKGROUND: Atypical fibroxanthoma (AFX) is a low-grade sarcoma usually occurring on sun-damaged skin of the head and neck in elderly patients.
The potential aggressiveness of AFX is controversial. OBSERVATIONS: We describe herein a patient who developed metastatic disease in cervical lymph nodes. 2019-11-08 · Atypical fibroxanthoma (AFX) is an uncommon, pleomorphic, spindle cell cutaneous malignancy that most commonly presents as a solitary red or pink papule or nodule on the head or neck (picture 1A) [ 1 ]. Exposure to ultraviolet light most likely contributes to the development of AFX.
Atypical fibroxanthoma of the skin. A clinicopathologic study of 140 cases. Cancer. 1973;31:1541-1552.
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Material and methods: We preformed a Jul 7, 2020 Atypical fibroxanthoma (AFX) has been considered as the non-infiltrating precursor lesion of pleomorphic dermal sarcoma (PDS), which shows Metastasis is unusual. Prevention.
Dermatol Surg. 2009; 35(5):765-72. Kargi E, Gungor E, Verdi M, Kuiaçogiu S, Erdogan B, Alli N, et al. Atypical fibroxanthoma and metastasis to the lung.
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Atypical fibroxanthoma (AFX) is a rare spindle cell neoplasm predominantly found on the head and neck of elderly individuals with sun-damaged skin, with no evidence-based guidelines for their management.
2010;146(12):1399-1404. 5.
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Higher reported rates of metastasis probably result from misdiagnosis of pleomorphic dermal sarcoma as AFX. Potential sites of metastases for AFX include
PubMed CrossRef Google Scholar New D, Bahrami S, Malone J, et al. (2010) Atypical fibroxanthoma with regional lymph node metastasis: Report of a case and review of the literature. Arch Dermatol 146: 1399-1404. Zschoche C, Hamsch C, Kutzner H, et al. (2014) Analysis of the lymphatic vessel architecture of atypical fibroxanthoma and pleomorphic dermal sarcoma. Cutaneous atypical fibroxanthoma (AFX) occurs in elderly persons as a small nodule or ulceronodule in actinically damaged skin of the head and neck area. The vast majority of AFX behave in a benign manner, and metastasis is rare.